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Comparative analysis of pathways controlling seasonal flowering in annual and perennial Brassicaceae species
发表时间:2015-10-26 阅读次数:1426次

报告人:  Dr. George Coupland
Director of Max Planck Institute for Plant Breeding Research
Address: Max Planck Institute for Plant Breeding Research, Carl-von-Linné Weg 10
D-50829 Cologne, Germany
Phone: +49 221 5062-205 Fax:+49 221 5062-207
Email: coupland@mpipz.mpg.de
Comparative analysis of pathways controlling seasonal flowering in annual and perennial Brassicaceae species
报告时间:2015年10月30日(星期五)   上午10:00
联 系 人: 张大兵 zhangdb@sjtu.edu.cn;021-34204869

Personnel Information:
University Education
1977 - 1984 Glasgow University, Department of Microbiology
- Graduated with First Class Honours in Microbiology
1981 - 1984 Edinburgh University, Department of Molecular Biology, Ph.D. with Professor Neil Willetts. Awarded a Ph.D. in Molecular Biology in December 1984
- Title of thesis: The transposable elements and conjugation system of the IncN plasmid R46
Post-Doctoral Experience
1985 - 1988 Institute for Genetics, University of Cologne and Max Planck Institute for Plant Breeding Research, Cologne
- Received a Royal Society European Exchange Fellowship and an EMBO long-term Fellowship to work as a post-doctoral fellow with Professor Peter Starlinger
Tenured positions
1989 - 2001 Research group leader at the Plant Breeding Institute, Cambridge, UK

In March 1990 moved with the Institute to the Cambridge Laboratory, John Innes Centre, Norwich.
2001 - In January 2001 appointed as a Director of the Max Planck Institute for Plant Breeding Research in Cologne
External appointments and Honours
 Honorary Lecturer at the University of East Anglia, 1993-2001

Honorary Professor at the University of Cologne, April 2003

Elected Member of European Molecular Biology Organisation, 2001

Elected Associate Member of the Class of Sciences of the Royal Academy of Belgium, 2006

Elected Fellow of the Royal Society, London, 2007

Elected Member to the German Academy of Sciences Leopoldina, 2009

Elected Member of Academia Europaea, UK, 2009

Faculty of 1000 Member, 2011
Elected foreign associate of the National Academy of Sciences, USA, 2012
De Montaigu, A., Giakountis, A., Rubin, M., Tóth, R., Cremer, F., Sokolova, V., Porri, A., Reymond, M., Weinig, C. and Coupland, G. (2015) Natural diversity in daily rhythms of gene expression contributes to phenotypic variation. Proceedings of the National Academy of Sciences 112, 905-910, doi: 10.1073/pnas.1422242112.
Fornara, F., de Montaigu, A., Sánchez-Villareal, A., Takahashi, Y., van Themaat, E.V., Huettel, B., Davis, S. and Coupland, G. (2015) The GI-CDF module of Arabidopsis affects freezing tolerance and growth as well as flowering. The Plant Journal 81, 695-706, doi: 10.1111/tpj.12759.
Hyun, Y., Kim, J., Woo Cho, S., Choi, Y., Kim, J-S. and Coupland, G. (2015) Site-directed mutagenesis in Arabidopsis thaliana using dividing tissue-targeted RGEN of the CRISPR/Cas system to generate heritable null alleles. Planta 241, 271–284, doi: 10.1007/s00425-014-2180-5.
Iglesias F.M., Bruera N.A., Dergan-Dylon S., Marino-Buslje, C., Lorenzi, H., Mateos J.L., Turck, F., Coupland, G. and Cerdán, P.D. (2015) The ArabidopsisDNA Polymerase δ Has a Role in the Deposition of Transcriptionally Active Epigenetic Marks, Development and Flowering. PLoS Genetics 11(2):e1004975. doi:10.1371/journal.pgen.1004975.
Krzymuski, M., Andrés, F., Cagnola, J.I., Jang, S., Yanovsky, M.J., Coupland, G. and Casal, J.J. (2015) The dynamics of FLOWERING LOCUS T expression encodes long-day information.The Plant Journal, DOI: 10.1111/tpj.12938
Mateos, J., Madrigal, P., Tsuda, K., Rawat, V., Richter, R., Romera-Branchat, M., Fornara, F., Schneeberger, K., Krajewski, P and Coupland, G. (2015) Combinatorial activities of SHORT VEGETATIVE PHASE and FLOWERING LOCUS C define distinct modes of flowering regulation in Arabidopsis. Genome Biology,16:31, doi: 10.1186/s13059-015-0597-1.
Sacharowski, S.P., Gratkowska, D.M., Sarnowska, E.A., Kondrak, P., Jancewicz, I., Porri, A., Bucior, E., Rolicka, A.T., Franzen, R., Kowalczyk, J., Pawlikowska, K., Huettel, B., Torti, S., Schmelzer, E., Coupland, G., Jerzmanowski, A., Koncz, C. and Sarnowski, T.J. (2015) SWP73 Subunits of Arabidopsis SWI/SNF Chromatin Remodelling Complexes Play Distinct Roles in Leaf and Flower Development. The Plant Cell, DOI 10.1105/tpc.15.00233
Simon, S., Rühl, M., de Montaigu, A., Wötzel, St. and Coupland, G. (2015) Evolution of CONSTANS Regulation and Function after Gene Duplication produced a Photoperiodic Flowering Switch in the Brassicaceae.
Molecular Biology and Evolution, doi: 10.1093/molbev/msv110
Toräng, P., Wunder, J., Ramón Obeso, J., Herzog, M., Coupland, G. and Agren, J. (2015) Large-scale adaptive differentiation in the alpine perennial herb Arabis alpina. New Phytologist 206, 459-470, doi:10.1111/nph.13176.
Willing E.M., Rawat V., Florian Maumus, Velikkakam James G., Nordström K.J.V., Becker C., Warthmann N., Chica C., Szarzynska B., Zytnicki M., Albani M. C., Kiefer C., Bergonzi S., Castaings L., Mateos J.L., Berns M.C., Bujdoso N., Piofczyk T., de Lorenzo L., Barrero-Sicilia C., Mateos I., Piednoël M., Hagmann J., Chen-Min-Tao R., Iglesias-Fernández R., Schuster S.C., Alonso-Blanco C., Roudier F., Carbonero P., Paz-Ares J., Davis S.J., Pecinka A., Quesneville H., Colot V., Lysak M.A., Weigel D., Coupland G. and Schneeberger K (2015)Genome expansion of Arabis alpina linked with retrotransposition and reduced symmetric DNA methylation. Nature Plants 1: 14023. doi:10.1038/nplants.2014.23
Andrés F, Porri A, Torti S, Mateos J, Romera-Branchat M, García-Martínez JL, Fornara F, Gregis V, Kater MM, Coupland G. (2014) SHORT VEGETATIVE PHASE reduces gibberellin biosynthesis at the Arabidopsis shoot apex to regulate the floral transition. Proceedings of the National Academy of Sciences111(26):E2760-9. doi: 10.1073/pnas.1409567111.
Berns, M. C., Nordström, K., Cremer, F., Tóth, R., Hartke, M., Simon, S., Klasen, J. R., Bürstel, I. and Coupland, G. (2014) Evening Expression of Arabidopsis GIGANTEA Is Controlled by Combinatorial Interactions among Evolutionarily Conserved Regulatory Motifs. Plant Cell, 26: 3999-4018, doi: tpc.114.129437v1-tpc.114.129437.
Castaings, L., Bergonzi, S., Albani, M. C., Kemi, U., Savolainen O and Coupland, G. (2014). Evolutionary conservation of cold-induced antisense RNAs ofFLOWERING LOCUS C in Arabidopsis thaliana perennial relatives. Nature communications, Jul 17, DOI: 10.1038/ncomms5457
Chopra, D., Wolff, H., Span, J., Schellmann, S., Coupland, G., Albani, M.C., Schrader, A. and Hülskamp, M. (2014). Analysis of TTG1 function in Arabis alpina. BMC Plant Biology 14:16.
Hu JY, Zhou Y, He F, Dong X, Liu LY, Coupland G, Turck F, de Meaux J (2014). miR824-Regulated AGAMOUS-LIKE16 Contributes to Flowering Time Repression in Arabidopsis. Plant Cell 26, 2024-2037.
Liu, L., Zhang, J., Adrian, J., Gissot, L., Coupland, G., Yu, D. and F. Turck (2014). Elevated Levels of MYB30 in the Phloem Accelerate Flowering in Arabidopsis through the Regulation of FLOWERING LOCUS T. PLoS ONE 9 (2): e89799,DOI: 10.1371/journal.pone.0089799.
Nakamura, Y., Andrés, F., Kanehara, K., Liu, Y.-c., Dörmann, P. and Coupland, G. (2014). Arabidopsis florigen FT binds to diurnally oscillating phospholipids that accelerate flowering. Nature Communications 5:3553.
Nakamura, Y., Andrés, F., Kanehara, K., Liu, YC., Coupland, G. and Dörmann, P. (2014) Diurnal and circadian expression profiles of glycerolipid biosynthetic genes in Arabidopsis. Plant signaling & Behavior, Jul 16, 9, e29715.
Pajoro, A., Biewers, S., Dougali, E., Leal Valentim, F., Mendes, M. A., Porri, A., Coupland, G., Van de Peer, Y., van Dijk, A. D. J., Colombo, L., Davies, B. and Angenent, G. C. (2014) The (r)evolution of gene regulatory networks controlling Arabidopsis plant reproduction; a two decades history. Journal of Experimental Botany, 65 (17), 4731-4745, doi:10.1093/jxb/eru233.
Suárez López, P., Tsuji, H. and Coupland, G. (2014) A tribute to Ko Shimamoto (1949 – 2013). Journal of Experimental Botany, 65 (22), 6755-6759.
Romera-Branchat, M., Andrés, F. and Coupland, G. (2014) Flowering responses to seasonal cues: what’s new? Current Opinion in Plant Biology, 21, 120 – 127.
Turck F, Coupland G. (2014) Natural variation in epigenetic gene regulation and its effects on plant developmental traits. Evolution 68, 620-631. (online publication 31.10.2013, doi:10.1111/evo.12286)
Villajuana-Bonequi, M., Elrouby, N., Nordström, K., Griebel, T., Bachmair, A. and Coupland, G. (2014) Elevated salicylic acid levels conferred by increased expression of ISOCHORISMATE SYNTHASE 1 contribute to hyperaccumulation of SUMO1 conjugates in the Arabidopsis mutant early in short days 4. The Plant Journal 79, 206-219, doi: 10.1111/tpj.12549.
Bergonzi, S., Albani, M. C., Ver Loren van Themaat, E., Nordström, K.J.V., Wang, R., Schneeberger, K., Moerland, P.D. and G. Coupland: Mechanisms of Age-Dependent Response to Winter Temperature in Perennial Flowering of Arabis alpina. Science 340, 6136, 1094 – 1097 (2013).
Elrouby, N., Villajuana Bonequi, M., Porri, A. and Coupland, G. Identification ofArabidopsis SUMO-interacting proteins that regulate chromatin activity and developmental transitions. Proc. Natl. Acad. Sci. 110 (49), 19956-19961 (2013)
Gregis, V., Andrés, F., Sessa, A., Guerra, R.F., Simonini, S., Mateos, J.L., Torti, S., Zambelli, F., Prazzoli, G.M., Bjerkan, K.N., Grini, P.E., Pavesi, G., Colombo, L. Coupland, G. and Kater, M.M. Identification of pathways directly regulated by SHORT VEGETATIVE PHASE during vegetative and reproductive development inArabidopsis. Genome Biology 14:R56, doi:10.1186/gb-2013-14-6-r56 (2013).
Nordström; K. J. V., Albani, M. C.; Velikkakam James, G.; Gutjahr, C.; Hartwig, B.; Turck, F.; Paszkowski, U.; Coupland, G. and K. Schneeberger: Mutation identification by direct comparison of whole-genome sequencing data from mutant and wild-type individuals using k-mers. Nature Biotechnology, advanced online publication, doi: 10.1038/nbt.2515 (2013).
Sarnowska, E.A.,  Rolicka, A.T., Bucior, E., Cwiek, P., Tohge, T., Fernie, A.R., Jikumaru, Y., Kamiya, Y., Franzen, R., Schmelzer, E., Porri, A., Sacharowski, S., Gratkowska, D.M., Zugaj, D.L., Taff, A., Zalewska, A.,  Archacki, R., Davis, S.J., Coupland, G., Koncz, C., Jerzmanowski, A. and Sarnowski, T.J. (2013). DELLA-Interacting SWI3C Core Subunit of Switch/Sucrose Nonfermenting Chromatin Remodeling Complex Modulates Gibberellin Responses and Hormonal Cross Talk in Arabidopsis. Plant Physiology 163, 305-317 (2013).
Tomanov, K., Hardtke, C., Budhiraja, R., Hermkes, R., Coupland, G. and Bachmair, A. Small Ubiquitin-Like Modifier Conjugating Enzyme with Active Site Mutation Acts as Dominant Negative Inhibitor of SUMO Conjugation inArabidopsis. Journal of Integrative Plant Biology, 55: 75–82. doi: 10.1111/jipb.12016 (2013).
Yamaguchi, N., Wu, M.-F., Winter, C.M., Berns, M.C., Nole-Wilson, S., Yamaguchi, A., Coupland, G., Krizek, B.A. and Wagner, D.: A Molecular Framework for Auxin-Mediated Initiation of Flower Primordia. Developmental Cell24, 271-282 (2013).
Albani, M.C., Castaings, L., Wötzel, S., Mateos, J.L., Wunder, J., Wang, R., Reymond, M. and Coupland, G. PEP1 of Arabis alpina Is Encoded by Two Overlapping Genes That Contribute to Natural Genetic Variation in Perennial Flowering. PLoS Genetics 8 (12): e1003130. doi:10.1371/journal.pgen.1003130 (2012).
Andrés, F. and Coupland, G. The genetic basis of flowering responses to seasonal cues. Nature Reviews Genetics 13, 627-639 (2012).
Koskela, E.A., Mouhu, K., Albani, M.C., Kurokura, T., Rantanen, M., Sargent, D.J., Battey, N.H., Coupland, G., Elomaa, P. and Hytönen, T. Mutation inTERMINAL FLOWER1 reverses the photoperiodic requirement for flowering in the wild strawberry, Fragaria vesca. Plant Physiology 159, 1043-1054 (2012).
Campoli, C., Drosse, B., Searle, I., Coupland, G. and von Korff, M.: Functional characterization of HvCO1, the barley (Hordeum vulgare) flowering time ortholog of CONSTANS. Plant Journal 69, 868-880 (2012).
Herrero, E., Kolmos, E., Bujdoso, N., Yuan, Y., Wang, M., Berns, M.C., Uhlworm, H., Coupland, G., Saini, R., Jaskolski, M., Webb, A., Gon?alves, J. and Davis, S.J.: EARLY FLOWERING4 Recruitment of EARLY FLOWERING3 in the Nucleus Sustains the Arabidopsis Circadian Clock. The Plant Cell 24, 428-443 (2012).
Porri, A., Torti, S., Romera-Branchat, M. and Coupland, G. Spatially distinct regulatory roles for gibberellins in the promotion of flowering of Arabidopsisunder long  photoperiods. Development 139, 2198-2209 (2012).
Terecskei, K., Tóth, R., Gyula, P., Kevei, E., Bindics, J., Coupland, G., Nagy, F. and Kozma-Bognár, L.: The circadian clock-associated small GTPase LIGHT INSENSITIVE PERIOD 1 suppresses light-controlled endoreplication and affects tolerance to salt stress in Arabidopsis. Plant Physiology, DOI:10.1104/pp.112.203356 (2012).
Tóth, R., Gerding-Reimers, C., Deeks, M.J., Menninger, S., Gallegos, R.M., Tonaco, I.A.N., Hübel, K., Hussey, P.J., Waldmann, H. and Coupland, G.:
Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. The Plant Journal 71, 338-352 (2012)
Torti, S., Fornara, F., Vincent, C., Andrés, F., Nordström, K., Göbel, U., Knoll, D., Schoof, H., and Coupland, G. : Analysis of the Arabidopsis Shoot Meristem Transcriptome during Floral Transition Identifies Distinct Regulatory Patterns and a Leucine-Rich Repeat Protein That Promotes Flowering. Plant Cell 24, 444-462 (2012).
open access
Castrillo, G., Turck, F., Leveugle, M., Lecharny, A., Carbonero, P., Coupland, G., Paz-Ares, J. and Oñate-Sánchez, L. Speeding Cis- Trans Regulation Discovery by Phylogenomic Analyses Coupled with Screenings of an Arrayed Library of Arabidopsis Transcription Factors. PLoS One 6 (6): e21524. doi: 10.1371/journal.pone.0021524 (2011).
open access

Castro Marín, I., I. Loef, L. Bartetzko, I. Searle, G. Coupland, M. Stitt and D. Osuna: Nitrate regulates floral induction in Arabidopsis, acting independently of light, gibberellin and autonomous pathways.. In: Planta 233, 539-552 (2011).
open access

Cominelli, E., Galbiati M., Albertini, A., Fornara, F., Conti, L., Coupland, G., Tonelli, C.: DOF-binding sites additively contribute to guard cell-specificity of AtMYB60 promoter. In: BMC Plant Biology 11:162, doi:10.1186/1471-2229-11-162 (2011).
open access

D’Aloia, M., Bonhomme, D., Bouché, F., Tamseddak, K., Ormenese, S., Torti, S., Coupland, G. and Périlleux, C.: Cytokinin promotes flowering of Arabidopsis via transcriptional activation of the FT paralogue TSF. Plant Journal 65, 972-979 (2011).

Dorca-Fornell, C.; Gregis, V.; Grandi, V.; Coupland, G.; Colombo, L.; Kater, M. M.: The Arabidopsis SOC1-like genes AGL42, AGL71 and AGL72 promote flowering in the shoot apical and axillary meristems. Plant Journal 67, 1006-1017 (2011).

Hermkes, R; Fu, Y F; Nürrenberg, K; Budhiraja, R; Schmelzer, E; Elrouby, N; Dohmen, R J; Bachmair, A; Coupland, G.: Distinct roles for Arabidopsis SUMO protease ESD4 and its closest homolog ELS1. Planta 233, 63-73 (2011).

Turck, F. and Coupland, G.: When vernalization makes sense. In: Science 331, 36-37 (2011).

Wang, R., Albani, M.C., Vincent, C., Bergonzi, S., Luan, M., Bai, Y., Kiefer, C., Castillo, R. and Coupland, G.: Aa TFL1 confers an age-dependent response to vernalization in perennial Arabis alpine. In: Plant Cell 23, 1307-1321 (2011).
open access


Albani, M. C. and G. Coupland: Comparative Analysis of Flowering in Annual and Perennial Plants. In: Plant Development. (Eds.) Timmermans, Marja C. P. Current Topics in Developmental Biology 91. Elsevier, Amsterdam (2010) 323-348.

Adrian, J., S. Farrona, J.J. Reimer, M.C. Albani, G. Coupland and F. Turck: cis-Regulatory Elements and Chromatin State Coordinately Control Temporal and Spatial Expression of FLOWERING LOCUS T in Arabidopsis. In: Plant Cell 22, 1425-1440 (2010).

de Montaigu, A., Tóth, R. and Coupland, G.: Plant development goes like clockwork. Trends in Genetics 26, 296-306 (2010).

Elrouby, N. and Coupland, G.: Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. In: Proc. Natl. Acad. Sci., 107, 17415-17420 (2010).

Fornara, F., de Montaigu, A. and Coupland, G..SnapShot: Control of flowering inArabidopsis. Cell 141, 550-550.e2, (2010).

Giakountis, A; Cremer, F; Sim, S; Reymond, M; Schmitt, J; Coupland, G.: Distinct patterns of genetic variation alter flowering responses of Arabidopsis accessions to different day lengths. In: Plant Physiology 152, 177-191 (2010).


Khanna, R., Kronmiller, B., Maszle, D.R., Coupland, G., Holm, M., Mizuno, T. and Wu, S.-H.: The Arabidopsis B-Box Zinc Finger Family. Plant Cell 21, 3416-3420 (2009).

Jang, S., Torti, S. and Coupland, G.: Genetic and spatial interactions betweenFT, TSF and SVP during the early stages of floral induction in Arabidopsis. Plant Journal 60, 614-625 (2009).

Budhiraja, R., R. Hermkes, S. Müller, J. Schmidt, J. Colby, K. Panigrahi, G. Coupland and A. Bachmair: Substrates Related to Chromatin and to RNA-Dependent Processes Are Modified by Arabidopsis SUMO Isoforms that Differ in a Conserved Residue with Influence on De-Sumoylation. In: Plant Physiology 149, 1529-1540 (2009).

Fornara, F; Coupland, G: Plant Phase Transitions Make a SPLash. In: Cell 138, 625-627 (2009).

Fornara, F., K. C. S. Panigrahi, L. Gissot, N. Sauerbrunn, M. Rühl, J. Jarillo and G. Coupland: Arabidopsis DOF Transcription Factors Act Redundantly to Reduce CONSTANS Expression and Are Essential for a Photoperiodic Flowering Response. In: Developmental Cell 17, 75-86 (2009).

Serrano, G; Herrera-Palau, R; Romero, J M; Serrano, A; Coupland, G; Valverde, F: Chlamydomonas CONSTANS and the Evolution of Plant Photoperiodic Signaling. In: Current Biology 19, 359-368. (2009).

Smith, A.M., G. Coupland, L. Dolan, N. Harberd, J. Jones, C. Martin, R. Sablowski and A. Amey (2009). Plant Biology. Garland Science, Taylor & Francis Group, New York.

Wang, R., S. Farrona, C. Vincent, A. Joecker, H. Schoof, F. Turck, C. Alonso-Blanco, G. Coupland and M. Albani: PEP1 regulates perennial flowering in Arabis alpina. In: Nature 459, 423-427 (2009).

Wilczek, A. M., J. L. Roe, M. C. Knapp, M. D. Cooper, C. Lopez-Gallego, L. J. Martin, C. D. Muir, S. Sim, A. Walker, J. Anderson, J. F. Egan, B. T. Moyers, R. Petipas, A. Giakountis, E. Charbit, G. Coupland, S. M. Welch and J. Schmitt: Effects of Genetic Perturbation on Seasonal Life History Plasticity. In: Science323, 930-934. (2009).

Yoshida, R., R. Fekih, S. Fujiwara, A. Oda, K. Miyata, Y. Tomozoe, M. Nakagawa, K. Niinuma, K. Hayashi, H. Ezura, G. Coupland and T. Mizoguchi: Possible role of EARLY FLOWERING 3 (ELF3) in clock-dependent floral regulation by SHORT VEGETATIVE PHASE (SVP) in Arabidopsis thaliana. In: New Phytologist 182, 838-850 (2009)


Benhamed, M., M.-L. Martin-Magniette, L. Taconnat, F. Bitton, C. Servet, R. De Clercq, B. De Meyer, C. Buysschaert, S. Rombauts, R. Villarroel, S. Aubourg, J. Beynon, R. P. Bhalerao, G. Coupland, W. Gruissem, F. L. H. Menke, B. Weisshaar, J.-P. Renou, D.-X. Zhou and P. Hilson: Genome-scale Arabidopsis promoter array identifies targets of the histone acetyltransferase GCN5. In: Plant Journal 56, 493 - 504 (2008).

Coupland, G: Mechanisms and variation in plant development: sorting the wood from the trees in Vermont. In: Development 135, 3813-3816 (2008).

Farrona, S., Coupland, G., Turck, F.: The impact of chromatin regulation on the floral transition. In: Seminars in Cell & Developmental Biology 19, 560-573 (2008).

Fujiwara, S; Oda, A; Yoshida, R; Niinuma, K; Miyata, K; Tomozoe, Y; Tajima, T; Nakagawa, M; Hayashi, K; Coupland, G; Mizoguchi, T: Circadian Clock Proteins LHY and CCA1 Regulate SVP Protein Accumulation to Control Flowering inArabidopsis. In: Plant Cell, 20, 2960-2971 (2008).

Giakountis, A; Coupland, G: Phloem transport of flowering signals. In: Current Opinion in Plant Biology 11, 687-694 (2008).

Jang, S., V. Marchal, K. C. Panigrahi, S. Wenkel, W. Soppe, X.-W. Deng, F. Valverde and G. Coupland: Arabidopsis COP1 shapes the temporal pattern of CO accumulation conferring a photoperiodic flowering response. In: Embo Journal27, 1277-1288 (2008).

Turck, F., F. Fornara and G. Coupland ¬: Regulation and Identity of Florigen: Flowering Locus T Moves Center Stage. In: Annual Review of Plant Biology 59, 573-94 (2008).


Corbesier, L., Vincent, C., Jang, S., Fornara, F., Fan, Q., Searle, I., Giakountis, A., Farrona, S., Gissot, L., Turnbull, C. and Coupland G. (2007). FT protein movement contributes to long-distance signalling in floral induction ofArabidopsis. Science 316, 1030-1033

Hayama, R., Agashe, B., Luley, E., King, R. and Coupland, G. (2007). A circadian rhythm set by dusk controls the expression of FT homologues and the short day photoperiodic flowering response in Pharbitis. The Plant Cell 19, Oct, 1 - 13

Turck, F., F. Roudier, S. Farrona, M.-L. Martin-Magniette, E. Guillaume, N. Buisine, S. Gagnot, R. A. Martienssen, G. Coupland* and V. Colot* (2007). Arabidopsis TFL2/LHP1 Specifically Associates with Genes Marked by Trimethylation of Histone H3 Lysine 27. PLOS Genetics 3, 6, 0855-0866. Seq. No.: doi:10.1371/journal.pgen.0030086
*Joint corresponding authors. 2006

Ben-Naim, O., Eshed, R., Parnis, A., Teper-Bamnolker, P., Shalit, A., Coupland, C., Samach, A. and Lifschitz, E. (2006). The CCAAT BINDING FACTOR can mediate interactions between CONSTANS-like proteins and DNA Plant Journal46, 462-476

Corbesier, L. and Coupland, G. (2006). The quest for florigen: a review of recent progress. Journal of Experimental Botany 57, No. 13, 3395-3403.

Coupland, G. (2006). The molecular genetics of photo-periodic responses: comparisons between long-day and short-day species. In Photomorphogenesis in Plants and Bacteria, 3rd Edition: Function and Signal Transduction Mechanisms, eds. E. Schäfer and F. Nagy. Springer, Dordrecht, pp 605-625.

Laubinger, S., Marchal, V., Gentilhomme, J., Wenkel, S., Adrian, J., Jang, S., Kulajta, C., Braun, H., Coupland, G. and Hoecker, U. (2006). Arabidopsis SPA proteins regulate photoperiodic flowering and interact with the floral inducer CONSTANS to regulate its stability. Development 133, 3213-3222.

Searle, I., He, Y., Turck, F., Vincent, C., Fornara, F., Kröber, S., Amasino, R. A. and Coupland, G. (2006). The transcription factor FLC confers a flowering response to vernalization be repressing meristem competence and systemic signaling in Arabidopsis. Genes & Development 20, 898-912.

Townsend, T; Albani, M; Wilkinson, M; Coupland, G; Battey, N (2006). The diversity and significance of flowering in perennials in: Flowering and its manipulation (Annual plant reviews vol. 20), S. 181-197

Wenkel, S., F. Turck, K. Singer, L. Gissota, J. Le Gourrierec, A. Samach and G. Coupland (2006). CONSTANS and the CCAAT Box Binding Complex Share a Functionally Important Domain and Interact to Regulate Flowering of Arabidopsis. Plant Cell 18, 2971-2984 .


Berendzen, K., Searle, I., Ravenscroft, D., Koncz, C., Batschauer, A., Coupland, G., Somssich, I.E. and Ülker, B. (2005). A rapid and versatile combined DNA/RNA extraction protocol and its application to the analysis of a novel DNA marker set polymorphic between Arabidopsis thaliana ecotypes Col-0 and Landsberg erecta. Plant Methods 2005, 1:4

Carré, I., Coupland, G. and Putterill, J. (2005). Photoperiodic responses and the regulation of flowering. In Endogenous Plant Rhythms (Annual Plant Reviews, Vol. 21), eds. A.J.W. Hall and H.G. McWatters. Blackwell Publishing Ltd., Oxford, pp 167-190.

Corbesier, L. and Coupland, G. (2005). Photoperiodic flowering of Arabidopsis: integrating genetic and physiological approaches to characterization of the floral stimulus. Plant, Cell and Environment 28, 54-66

Coupland, G. (2005). Intercellular communication during floral initiation and development. Intercellular Communication in Plants (Annual Plant Reviews, Vol. 16), ed. A.J. Fleming. Blackwell Publishing Ltd. , Oxford, pp 178-198.

Coupland, G. and Prat Monguio, S. (2005). Signalling mechanisms in plants: examples from the present and the future. (Editorial overview, Cell signalling and gene regulation) Current Opinion in Plant Biology 8, 457-461.

Mizoguchi, T., Wright, L., Fujiwara, S., Cremer, F., Lee, K., Onouchi, H., Mouradov, A., Fowler, S., Kamada, H., Putterill, J. and Coupland, G. (2005). Distinct roles of GIGANTEA in promoting flowering and regulating circadian rhythms in Arabidopsis. Plant Cell 17, 2255-2270. (Abstract) (Full Text)

Zobell, O., Coupland, G. and Reiss, B. (2005). The family of CONSTANS-like genes in Physcomitrella patens. Plant Biology 7, 266-275.

An, H., Roussot, C., Suárez-López, P., Corbesier, L., Vincent, C., Piñeiro, M., Hepworth, S., Mouradov, A., Justin, S., Turnbull, C. and Coupland, G. (2004). CONSTANS acts in the phloem to regulate a systemic signal that induces photoperiodic flowering of Arabidopsis. Development 131, 3615-3626 ( PDF)


Casal, J.J., Fankhauser, C., Coupland, G. and Blázquez, M.A. (2004). Signalling for developmental plasticity. Trends in Plant Science 9, 309-314.

Hayama, R. and Coupland, G. (2004) The Molecular Basis of Diversity in the Photoperiodic Flowering Responses of Arabidopsis and Rice. Plant Physiology135, 677-684

Novatchkova, M., Budhiraja, R., Coupland, G., Eisenhaber, F. and Bachmair, A. (2004). SUMO conjugation in plants. Planta 220, 1-8.

Oda, A., Fujiwara, S., Kamada, H., Coupland, G. and Mizoguchi, T. (2004). Antisense suppression of the Arabidopsis PIF3 gene does not affect circadian rhythms but causes early flowering and increases FT expression. FEBS Letters557, 259-264.

Searle, I. and Coupland, G. (2004). Induction of flowering by seasonal changes in photoperiod. The EMBO Journal 23, 1217-1222.

Valverde, F., Mouradov, A., Soppe, W., Ravenscroft, D., Samach, A. and Coupland, G. (2004). Photoreceptor regulation of CONSTANS protein in photoperiodic flowering. Science 303, 1003-1006. ( abstract) ( full text)


Cremer, F. and Coupland, G. (2003). Distinct photoperiodic responses are conferred by the same genetic pathway in Arabidopsis and in rice. Trends in Plant Science 8, 405-407.

Griffiths, S., Dunford, R.P., Coupland, G. and Laurie, D.A. (2003). The evolution of CONSTANS-like gene families in barley, rice and Arabidopsis. Plant Physiology 131, 1855-1867.

Hayama, R. and Coupland, G. (2003). Shedding light on the circadian clock and the photoperiodic control of flowering. Current Opinion in Plant Biology 6, 13-19.

Lao, N. T., Long, D., Kiang, S., Coupland, G., Shoue, D. A., Carpita, N. C., Kavanagh, T. A., (2003). Mutation of a family 8 glycosyltransferase gene alters cell wall carbohydrate composition and causes a humidity-sensitive semi-sterile dwarf phenotype in Arabidopsis. Plant Molecular Biology 53 (5), 687-701.

Murtas, G., Reeves, P.H., Fu, Y.-F., Bancroft, I., Dean, C. and Coupland, G. (2003). A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates. Plant Cell 15, 2308-2319.

Piñeiro, M., Gómez-Mena, C., Schaffer, R, Martínez-Zapater, J.M. and Coupland, G. (2003). EARLY BOLTING IN SHORT DAYS is related to chromatin remodeling factors and regulates flowering in Arabidopsis by repressing FT. Plant Cell 15, 1552-1562.


Cecchini, E., Geri, C., Love, A.J., Coupland, G., Covey, S.N. and Milner, J.J. (2002). Mutations that delay flowering in Arabidopsis de-couple symptom response from cauliflower mosaic virus accumulation during infection. Molecular Plant Pathology 3, 81-90.

Hepworth, S. R., Valverde, F., Ravenscroft, D., Mouradov, A. and Coupland, G. (2002). Antagonistic regulation of flowering-time gene SOC1 by CONSTANS and FLC via seperate promoter motifs. EMBO Journal 21, 4327-4337.

Lawand, S., Dorne, A.-J., Long, D., Coupland, G., Mache, R., Carol, P. (2002). Arabidopsis A BOUT DE SOUFFLE, which is homologous with mammalian carnitine acyl carrier, is required for postembryonic growth in the light. Plant Cell 14, 2161-2173.

Mizoguchi, T., Wheatley, K., Hanzawa, Y., Wright, L., Mizoguchi, M., Song, H-R., Carré, I.A. and Coupland, G. (2002). LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis. Developmental Cell 2, 629-641.

Mouradov, A., Cremer, F. and Coupland, G. (2002). Control of flowering time: Interacting pathways as a basis for diversity. Plant Cell 14, Supplement, S111-S130.

Reeves, P.H., Murtas, G., Dash, S. and Coupland, G. (2002). early in short days 4, a mutation in Arabidopsis that causes early flowering and reduces the mRNA abundance of the floral repressor FLC. Development 129, 5349-5361.


Gómez-Mena, C., Piñeiro, M., Franco-Zorrilla, J.M., Salinas, J., Coupland, G. and Martínez-Zapater, J.M. (2001). early bolting in short days: An Arabidopsis mutation that causes early flowering and partially suppresses the floral phenotype of leafy. Plant Cell 13, 1011-1024.

Reeves, P.H. and Coupland, G. (2001). Analysis of flowering time control in Arabidopsis by comparison of double and triple mutants. Plant Physiology 126, 1085-1091.

Robson, F., Costa, M.M.R., Hepworth, S.R., Vizir, I., Pineiro, M., Reeves, P.H., Putterill, J. and Coupland, G. (2001). Functional importance of conserved domains in the flowering-time gene CONSTANS demonstrated by analysis of mutant alleles and transgenic plants. Plant Journal 28, 619-631.

Roslan, H.A., Salter, M.G., Wood, C.D., White, M.R.H., Croft, K.P., Robson, F., Coupland, G., Doonan, J., Laufs, P., Tomsett, A.B., Caddick, M.X. (2001). Characterization of the ethanol-inducible alc gene-expression system in Arabidopsis thaliana. Plant Journal 28, 225-235.

Suárez-López, P., Wheatley, K., Robson, F., Onouchi, H., Valverde, F. and Coupland, G. (2001). CONSTANS mediates between the circadian clock and control of flowering in Arabidopsis. Nature 410, 1116-1120.


Hanzawa, Y., Takahashi, T., Michael, A.J., Burtin, D., Long, D., Pineiro, M., Coupland, G. and Komeda, Y. (2000). ACAULIS 5, an Arabidopsis gene required for stem elongation, encodes a spermine synthase. EMBO Journal 19, 4248-4256.

Mizoguchi, T. and Coupland, G. (2000). ZEITLUPE and FKF1: novel connections between flowering time and circadian clock control. Trends in Plant Science 5, 409-411.

Onouchi, H., Igeño, M.I., Perilleux, C., Graves, K. and Coupland, G. (2000). Mutagenesis of plants overexpressing CONSTANS demonstrates novel interactions among Arabidopsis flowering-time genes. Plant Cell 12, 885-900.

Putterill, J. and Coupland, G. (2000). Map-based cloning in Arabidopsis. Arabidopsis (The Practical Approch Series, Vol. 223), ed Z.A. Wilson, Oxford University Press, Oxford/UK, pp 171-197.

Reeves, P.H. and Coupland, G. (2000). Response of plant development to environment: control of flowering by daylength and temperature. Current Opinion in Plant Biology 3, 37-42.

Samach, A. and Coupland, G. (2000). Time measurement and the control of flowering in plants. BioEssays 22, 38-47.

Samach, A., Onouchi, H., Gold, S.E., Ditta, G.S., Schwarz-Sommer, Zs., Yanofsky, M.F. and Coupland, G. (2000). Distinct roles of CONSTANS target genes in reproductive development of Arabidopsis. Science 288, 1613-1616.


Carol, P., Stevenson, D., Bisanz, C., Breitenbach, J., Sandmann, G., Mache, R., Coupland, G. and Kuntz, M. (1999). Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. Plant Cell 11, 57-68.

Fowler, S., Lee, K., Onouchi, H., Samach, A., Richardson, K., Morris, B., Coupland, G. and Putterill, J. (1999). GIGANTEA: a circadian clock-controlled gene that regulates photoperiodic flowering in Arabidopsis and encodes a protein with several possible membrane-spanning domains. EMBO Journal 18, 4679-4688.


Alonso-Blanco, C., El-Din El-Assal, S., Coupland, G. And Koornneef, M. (1998). Analysis of natural allelic variation at flowering time loci in the Landsberg erecta and Cape Verde Islands ecotypes of Arabidopsis thaliana. Genetics 149, 749-764.

Coupland, G. (1998). Photoperiodic regulation of flowering time in Arabidopsis. In: Biological Rhythms and Photoperiodism in Plants, eds. P.J. Lumsden and A.J. Millar. BIOS Scientific Publishers Ltd., Oxford, pp 243-255.

Long, D. and Coupland, G. (1998). Transposon tagging with Ac /Ds in Arabidopsis. In: Arabidopsis Protocols (Vol 82 of Methods in Molecular Biology), eds J. Martinez-Zapater and J. Salinas. Humana Press, Totowa, New Jersey, pp 315-328.

Onouchi, H. and Coupland, G. (1998). The regulation of flowering time in response to daylength. Journal of Plant Research 111, 271-275.

Piñeiro, M. and Coupland, G. (1998). The control of flowering time and floral identity in Arabidopsis. Plant Physiology 117, 1-8.

Robert, L.S., Robson, F., Sharpe, A., Lydiate, D. and Coupland, G. (1998). Conserved structure and function of the Arabidopsis flowering time gene CONSTANS in Brassica napus. Plant Molecular Biology 37, 763-772.

Schaffer, R., Ramsay, N., Samach, A., Corden, S., Putterill, J., Carré, I.A. and Coupland, G. (1998). The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. Cell 93, 1219-1229.

Suárez-López, P. and Coupland, G. (1998). Plants see the blue light. Science 279, 1323-1324.


Coupland, G. (1997). Regulation of flowering by photoperiod in Arabidopsis. Plant, Cell and Environment 20, 785-789.

Coupland, G., Igeño, M.I., Simon, R. Schaffer, R., Murtas, G. Reeves, P., Robson, F., Pineiro, M., Costa, M., Lee, K. and Suárez-López, P. (1997). The regulation of flowering time by daylength in Arabidopsis. The Society for Experimental Biology SEB 1036, 105-110.

Davies, G.J., Sheikh M.A., Ratcliffe, O.J., Coupland, G. and Furner, I.J. (1997). Genetics of homology-dependent gene silencing in Arabidopsis; a role for methylation. Plant Journal 12, 791-804.

Fray, M.J., Puangsomlee, P., Goodrich, J., Coupland, G., Evans, E.J., Arthur, A.E. and Lydiate, D.J. (1997). The genetics of stamenoid petal production in oilseed rape (Brassica napus) and equivalent variation in Arabidopsis thaliana. Theoretical and Applied Genetics 94, 731-736.

Goodrich, J., Puangsomlee, P., Martin, M., Long, D., Meyerowitz, E.M. and Coupland, G. (1997). A Polycomb-group gene regulates homeotic gene expression in Arabidopsis. Nature 386, 44-51.

Long, D., Goodrich, J., Wilson, K., Sundberg, E., Martin, M., Puangsomlee, P. and Coupland, G. (1997). Ds elements on all five Arabidopsis chromosomes and assessment of their utility for transposon tagging. Plant Journal 11, 145-148.

Putterill, J.J., Ledger, S.E., Lee, K., Robson, F., Murphy, G. and Coupland, G. (1997). The flowering time gene CONSTANS and homologue CONSTANS LIKE 1 exist as a tandem repeat on chromosome 5 of Arabidopsis. Plant Physiology 114, 396.

Sundberg, E., Slagter, J.G., Fridborg, I., Cleary, S.P., Robinson, C. and Coupland, G. (1997). Albino3, an Arabidopsis nuclear gene essential for chloroplast differentiation, encodes a chloroplast protein that shows homology to proteins present in bacterial membranes and yeast mitochondria. Plant Cell 9, 717-730.


Lagercrantz, U., Putterill, J., Coupland, G. and Lydiate, D. (1996). Comparative mapping in Arabidopsis and Brassica, fine scale genome collinearity and congruence of genes controlling flowering time. Plant Journal 9, 13-20.

Simon, R. and Coupland, G. (1996). Arabidopsis genes that regulate flowering time in response to day-length. Seminars in Cell and Developmental Biology. 7, 419-425.

Simon, R., Igeño, M.I. and Coupland, G. (1996). Activation of floral meristem identity genes in Arabidopsis. Nature 384, 59-62.

Wilson, K., Long, D., Swinburne, J. and Coupland, G. (1996). A Dissociationinsertion causes a semidominant mutation that increases expression of TINY, an Arabidopsis gene related to APETALA2. Plant Cell 8, 659-671.


Coupland, G. (1995). Genetic and environmental control of flowering time inArabidopsis. Trends in Genetics 11, 393-397.

Coupland, G. (1995). LEAFY blooms in aspen. Nature 377, 482-483.

Coupland, G. (1995). Regulation of flowering time: Arabidopsis as a model system to study genes that promote or delay flowering. Philosophical Transactions Royal Society London B 350, 27-34.

Putterill, J., Robson, F., Lee, K., Simon, R. and Coupland, G. (1995). TheCONSTANS gene of Arabidopsis promotes flowering and encodes a protein showing similarities to zinc finger transcription factors. Cell 80, 847-857.



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