主要经历：

1998.09-2002.07，南京大学，生命科学学院，学士

2002.09-2006.05，南京大学，生命科学学院，博士

2006.06-2009.12，上海交通大学生命科学与技术学院，助理研究员

2008.07-2008.09，斯洛文尼亚，国家生物技术研究所，访问学者

2008.06-2008.07，比利时，农林渔业研究所，访问学者

2010.01-2016.12，上海交通大学生命科学与技术学院，副教授

2013.12-2014.12，美国，加州大学河滨分校，访问学者

2017.01-至今，上海交通大学生命科学与技术学院，教授

学术兼职：

2015年-至今 欧盟转基因生物安全检测实验室网络官方会议 永久观察员

2014年-至今  国际标准化组织“Molecular Analysis”分委会委员

面对转基因生物研发和产业化的国家需求以及转基因生物安全性的学科前沿，重点围绕转基因产品分子特征识别、检测和方法标准化开展理论和创新研究工作，建立转基因产品分子特征精准、全面的识别新策略和算法，攻克转基因产品中多靶标DNA特异性捕获、富集和识别的难题，系统建立了我国主要转基因产品分子特征检测方法、标准和标准物质。

1)        Yifei Ren, Yueming Liu, Xiang Li, Yang L, Yicun Cai, Sheng Quan, Liangwen Pan, Shunsheng Chen. A novel quantitative real-time PCR method for identification and quantification of mammalian and poultry species in foods. Food Control. 2017. 76: 42~51.

2)        Shao N, Chen J, Hu J, Li R, Zhang D, Guo S, Hui J, Liu P, Yang L, Tao SC. Visual detection of multiple genetically modified organisms in a capillary array. Lab Chip. 2017. 17(3): 521-529.

3)        Hong J, Yang L, Zhang D, Shi J. Plant Metabolomics: An Indispensable System Biology Tool for Plant Science. Int J Mol Sci. 2016. 17(6).

4)        Cheng F, Wu J, Zhang J, Pan A, Quan S, Zhang D, Kim H, Li X, Zhou S, Yang L. Development and inter-laboratory transfer of a decaplex polymerase chain reaction assay combined with capillary electrophoresis for the simultaneous detection of ten food allergens. Food Chem. 2016. 199:799-808.

5)        Rao J, Yang L, Guo J, Quan S, Chen G, Zhao X, Zhang D, Shi J. Metabolic changes in transgenic maize mature seeds over-expressing the Aspergillus niger phyA2. Plant Cell Rep. 2016. 35(2):429-37.

6)        Wei J, Le H, Pan A, Xu J, Li F, Li X, Quan S, Guo J, Yang L. Collaborative trial for the validation of event-specific PCR detection methods of genetically modified papaya Huanong No.1. Food Chem. 2016. 194:20-5.

7)        Wang C, Li R, Quan S, Shen P, Zhang D, Shi J, Yang L. GMO detection in food and feed through screening by visual loop-mediated isothermal amplification assays. Anal Bioanal Chem. 2015. 407(16):4829-34.

8)        Pi L, Li X, Cao Y, Wang C, Pan L, Yang L. Development and application of a multi-targeting reference plasmid as calibrator for analysis of five genetically modified soybean events. Anal Bioanal Chem. 2015, 407: 2877-86.

9)        Shao N, Jiang SM, Zhang M, Wang J, Guo SJ, Li Y, Jiang HW, Liu CX, Zhang DB, Yang L, Tao SC. MACRO: A Combined Microchip-PCR and Microarray System for High-Throughput Monitoring of Genetically Modified Organisms. Anal Chem. 2014. 86: 1269-1276.

10)     Milavec M, Dobnik D, Yang L, Zhang D, Gruden K, Zel J. GMO quantification: valuable experience and insights for the future. Anal Bioanal Chem. 2014. 406: 6485-97.

11)     Wang J, Yang L, Zhao X, Li J, Zhang D. Characterization and phylogenetic analysis of allergenic Tryp_alpha_amyl protein family in plants. J Agric Food Chem. 2014. 62: 270-8.

12)     Yang L, Wang C, Holst-Jensen A, Morisset D, Lin Y, Zhang D. Characterization of GM events by insert knowledge adapted re-sequencing approaches. Scientific Rep. 2013. 3: 2839.

13)     Zhang M, Liu Y, Chen L, Quan S, Jiang S, Zhang D, Yang L. One simple DNA extraction device and its combination with modified visual loop-mediated isothermal amplification for rapid on-field detection of genetically modified organisms. Anal Chem. 2013. 85: 75-82.

14)     Wei J, Li F, Guo J, Li X, Xu J, Wu G, Zhang D, Yang L. Collaborative Ring Trial of the Papaya Endogenous Reference Gene and Its Polymerase Chain Reaction Assays for Genetically Modified Organism Analysis. J Agric Food Chem. 2013. 61: 11363-11370.

15)     Rao J, Yang L, Wang C, Zhang D, Shi J. Digital gene expression analysis of mature seeds of transgenic maize overexpressing Aspergillus niger phyA2 and its non-transgenic counterpart. GM Crops Food. 2013. 4: 98-108.

16)     Wu Y, Yang L, Cao Y, Song G, Shen P, Zhang D, Wu G.Collaborative validation of an event-specific quantitative real-time PCR method for genetically modified rice event TT51-1 detection. J Agric Food Chem. 2013. 61: 5953-60.

17)     Huang H, Cheng F, Wang R, Zhang D, Yang L. Evaluation of four endogenous reference genes and their real-time PCR assays for common wheat quantification in GMOs detection. Plos One. 2013. 8: e75850.

18)     Zhang M, Liu Y, Chen L, Quan S, Jiang S, Zhang D, Yang L. One simple DNA extraction device and its combination with modified visual loop-mediated isothermal amplification for rapid on-field detection of genetically modified organisms. Anal Chem. 2013 Jan 2; 85(1):75-82.

19)     Yang C, Zhang D, Yang L. Development of event-specific PCR detection methods for genetically modified tomato Huafan No. 1. J Sci Food Agric. 2013 Feb; 93(3):652-60.

20)     Meng Y, Liu X, Wang S, Zhang D, Yang L. Applicability of Plasmid Calibrant pTC1507 in Quantification of TC1507 Maize: An Inter-laboratory Study. J Agric Food Chem. 2012. 60: 23-8.

21)     Guo J, Chen L, Liu X, Gao Y, Zhang D, Yang L. Multiplex degenerate PCR analytical approach targeting to eight genes for screening GMOs. Food Chem, 2012. 132: 1566-73.

22)     Li X, Pan L, Li J, Zhang Q, Zhang S, Lv R, Yang L. Establishment and application of event-specific polymerase chain reaction methods for two genetically modified soybean events, A2704-12 and A5547-127. J Agric Food Chem. 2011. 59: 13188-94.

23)     Chen L, Guo J, Wang Q, Kai G, Yang L. Development of the Visual Loop-Mediated Isothermal Amplification Assays for Seven Genetically Modified Maize Events and Their Application in Practical Samples Analysis. J Agric Food Chem. 2011, 59: 5914-8.

24)     Zhu X, Chen L, Shen P, Jia J, Zhang D, Yang L. High sensitive detection of Cry1Ab protein using a quantum dot-based fluorescence-linked immunosorbent assay. J Agric Food Chem. 2011, 59:2184-9.

25)     Guo J, Yang L, Chen L, Morisset D, Li X, Pan L, Zhang D.MPIC: A High-Throughput Analytical Method for Multiple DNA Targets. Anal Chem. 2011. 83: 1579–1586

26)     Zhi QM, Yang L, Sun HC. Protective effect of ambroxol against paraquat-induced pulmonary fibrosis in rats. Intern Med. 2011, 50:1879-87.

27)     Zhi Q, Sun H, Qian X, Yang L. Edaravone, a novel antidote against lung injury and pulmonary fibrosis induced by paraquat? Int Immunopharmacol. 2011, 1:96-102.

28)     Jiang LX, Yang L, Rao J, Guo JC, Wang S, Liu J, Lee SH, Zhang DB. Development and In-house Validation of the Event-specific Qualitative and Quantitative PCR Detection Methods for Genetically Modified Cotton MON15985. J Sci Food Agric. 2010; 90: 402-8.

29)     Wang C, Jiang L, Rao J, Liu Y, Yang L, Zhang D. Evaluation of four genes in rice for their suitability as endogenous reference standards in quantitative PCR. J Agric Food Chem. 2010, 58:11543-7.

30)     Xiaoyan Guan, Jinchao Guo, Ping Shen, Yang L, Dabing Zhang. Visual and Rapid Detection of Two Genetically Modified Soybean Events Using Loop-mediated Isothermal Amplification Method. Food Analytical Methods. 2010, 3: 313-320.

31)     Shen K, Li X, Wang S, Pan Y, Shi Z, Sun Y, Yang L. Establishment and in-house validation of simplex and duplex PCR methods for event-specific detection of maize SYN-E3272-5 using a new reference molecule. J AOAC Int. 2010. 93:663-75.

32)     Liu D, Shen J, Yang L, Zhang D. Evaluation of the impacts of different nuclear DNA content in the hull, endosperm, and embryo of rice seeds on GM rice quantification. J Agric Food Chem. 2010. 58:4582-7.

33)     Papazova N, Zhang D, Gruden K, Vojvoda J, Yang L, Buh Gasparic M, Blejec A, Fouilloux S, De Loose M, Taverniers I. Evaluation of the reliability of maize reference assays for GMO quantification. Anal Bioanal Chem. 2010. 396:2189-201.

34)     Huifeng Shen, Bingjun Qian, Yang L, Wanqi Liang, Weiwei Chen, Zhenhua Liu and Dabing Zhang. Estimation of the homoplasmy degree for transplastomic tobacco using quantitative real-time PCR. European Food Research and Technology, 2010, 143-150.

35)     Shen H, Qian B, Chen W, Liu Z, Yang L, Zhang D, Liang W. Immunogenicity of recombinant F4 (K88) fimbrial adhesin FaeG expressed in tobacco chloroplast. Acta Biochim Biophys Sin (Shanghai). 2010. 42:558-67.

36)     Shu Wang, Xiang Li, Yang L, Kailin Shen, Dabing Zhang. Development and in-house validation of a reference molecule pMIR604 for simplex and duplex event-specific identification and quantification of GM maize MIR604. Euro Food Res Tech. 2009. 230:239–248.

37)     Li X, Yang L, Zhang J, Wang S, Shen K, Pan L, Zhang D. Simplex and duplex polymerase chain reaction analysis of Herculex RW (59122) maize based on one reference molecule including separated fragments of 5' integration site and endogenous gene. J AOAC Int. 2009. 92:1472-83.

38)     Liu J, Guo J, Zhang H, Li N, Yang L, Zhang D. Development and in-house validation of the event-specific polymerase chain reaction detection methods for genetically modified soybean MON89788 based on the cloned integration flanking sequence. J Agric Food Chem. 2009. 57:10524-30.

39)     Guo J, Yang L, Liu X, Zhang H, Qian B, Zhang D. Applicability of the chymopapain gene used as endogenous reference gene for transgenic huanong no. 1 papaya detection. J Agric Food Chem. 2009. 57:6502-9.

40)     Guo J, Yang L, Liu X, Guan X, Jiang L, Zhang D. Characterization of the exogenous insert and development of event-specific PCR detection methods for genetically modified Huanong No. 1 papaya. J Agric Food Chem. 2009. 57:7205-12.

41)     Jiang L, Yang L, Zhang H, Guo J, Mazzara M, Van den Eede G, Zhang D. International collaborative study of the endogenous reference gene, sucrose phosphate synthase (SPS), used for qualitative and quantitative analysis of genetically modified rice. J Agric Food Chem. 2009. 57: 3525-32.

42)     Zhang HB, Yang L, Guo JC, Li XH, Feng YM, Zhang DB. Simultaneous detection of Listeria monocytogenes, Staphylococcus aureus, Salmonella enterica and Escherichia coli O157:H7 in food samples using multiplex PCR method. J Food Safety. 2009. 29, 348–363.

43)     Zhang H, Yang L, Guo J, Li X, Jiang L, Zhang D. Development of one novel multiple-target plasmid for duplex quantitative PCR analysis of roundup ready soybean. J Agric Food Chem. 2008. 56: 5514-20.

44)     Yang L, Liang W, Jiang L, Li W, Cao W, Wilson ZA, Zhang D. A novel universal real-time PCR system using the attached universal duplex probes for quantitative analysis of nucleic acids. BMC Mol Biol. 2008. 9:54.

45)     Dong W, Yang L, Shen K, Kim B, Kleter GA, Marvin HJ, Guo R, Liang W, Zhang D. GMDD: a database of GMO detection methods. BMC Bioinformatics. 2008. 9: 260.

46)     Yang L, Zhang H, Guo J, Pan L, Zhang D. International collaborative study of the endogenous reference gene LAT52 used for qualitative and quantitative analyses of genetically modified tomato. J Agric Food Chem. 2008. 56: 3438-43.

47)     Yang L, Guo J, Zhang H, Liu J, Zhang D. Qualitative and quantitative event-specific PCR detection methods for oxy-235 canola based on the 3' integration flanking sequence. J Agric Food Chem. 2008. 56:1804-9.

48)     Yang L, Guo J, Pan A, Zhang H, Zhang K, Wang Z, Zhang D. Event-specific quantitative detection of nine genetically modified maizes using one novel standard reference molecule. J Agric Food Chem. 2007. 55:15-24.

49)     Pan L, Zhang S, Yang L, Broll H, Tian F, Zhang D. Interlaboratory trial validation of an event-specific qualitative polymerase chain reaction-based detection method for genetically modified RT73 rapeseed. J AOAC Int. 2007. 90:1639-46.

50)     Yang L, Pan A, Zhang H, Guo J, Yin C, Zhang D. Event-specific qualitative and quantitative polymerase chain reaction analysis for genetically modified canola T45. J Agric Food Chem. 2006. 54:9735-40.

51)     Pan AH, Yang L, Xu SC, Yin CS, Zhang KW, Wang ZY, Zhang DB. Event-specific qualitative and quantitative PCR detection of MON863 maize based upon the 3’-transgene integration sequence. J Cereal Sci. 2006. 43: 250-257.

52)     Zhao ZH, Yang L, Ai XJ, Zhang DB, Zou SX. Influence of Genetically Modified Rice Containing codA Gene on Physiological Metabolism and Genetic Horizontal Transformation in Fed Rats. Chinese Journal of Agricultural Biotechnology. 2006. 3, 65-70.

53)     Yang L, Chen JX, Huang C, Liu YH, Jia SR, Pan LW, Zhang DB. Validation of a cotton-specific gene, Sad1, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic cottons. Plant Cell Rep. 2005. 24: 237-245.

54)     Yang L, Ding JY, Zhang CM, Jia JW, Weng HB, Liu WX, Zhang DB. Estimating the copy number of transgenes in transformed rice by real-time quantitative PCR. Plant Cell Rep. 2005. 23:759-763.

55)     Yang L, Pan A, Zhang KW, Yin CS, Qian BJ, Chen JX, Huang C, Zhang DB. Qualitative and Quantitative PCR Methods for Event-specific Detection of Genetically Modified Cotton Mon1445 and Mon531. Transgenic Res. 2005. 14: 817-831.

56)     Yang L, Pan AH, Jia JW, Ding JY, Chen JX, Cheng H, Zhang CM, Zhang DB. Validation of a tomato-specific gene, LAT52, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic tomatoes. J Agric Food Chem. 2005. 53:183-190.

57)     Yang L, Pan AH, Zhang KW, Guo JC, Yin CS, Chen JX, Huang C, Zhang DB. Identification and quantification of three genetically modified insect resistant cotton lines using conventional and TaqMan real-time polymerase chain reaction methods. J Agric Food Chem. 2005. 53: 6222-6229.

58)     Yang L, Shen HF, Pan AH, Chen JX, Huang C, Zhang DB. Screening and construct specific detection methods of transgenic Huafan No.1 tomato by conventional and real-time PCR. J Sci Food Agri. 2005. 85: 2159-2166.

59)     Yang L, Xu SC, Pan AH, Yin CS, Zhang KW, Wang ZY, Zhou ZG, Zhang DB. Event-specific qualitative and quantitative PCR detection of genetically modified MON863 maize based on the 5’-transgene integration sequence. J Agric Food Chem. 2005. 53: 9312-9318.

60)     Weng HB, Yang L, Liu ZL, Ding JY, Pan AH, Zhang DB. Novel reference gene, High-mobility-group protein I/Y, used in qualitative and real-time quantitative polymerase chain reaction detection of transgenic rapeseed cultivars. J AOAC Int. 2005. 88: 577-84.

61)     Ding JY, Jia JW, Yang L, Weng HB, Zhang CM, Liu WX, Zhang DB. Validation of a rice specific gene, sucrose phosphate synthase, used as the endogenous reference gene for qualitative and real-time quantitative PCR detection of transgenes. J Agric Food Chem. 2004. 52: 3372-3377.

62)     Weng HB, Aihu Pan, Yang L, Chengmei Zhang, Zhili Liu, Dabing Zhang. Estimating Transgene Copy number by Real -time PCR Assay using HMG I/Y as an Endogenous Reference Gene in Transgenic Rapeseed. Plant Mol. Bio. Rep. 2004. 22: 289–300.

研究成果：

重点围绕分子特征识别、检测的科学问题和技术难点，突破了分子特征准确识别、多靶标高通量精准检测和标准化的理论和技术难点，系统建立了转基因生物分子特征识别、检测和方法标准化体系， 取得了如下成果：

1）针对转基因产品数量多、分子特征检测通量低等问题，攻克了靶标 DNA 捕获、富集和特异性识别的技术难点，为分子特征高通量、快速检测新方法建立提供理论依据，开发了 4 种高通量、快速、精准核酸分析新方法（vLAMP、MPIC、 MACRO、 CALM）；

2） 针对分子特征识别技术不全面、不准确的问题，建立了精准、高通量分子特征识别新策略和算法（TranSeq），准确揭示了我国研发的17种重要转基因生物分子特征，为我国农业转基因生物安全审批和管理提供了科学判断依据；

3）针对我国转基因分子特征检测方法不系统、标准化程度低的不足，系统建立和验证了我国44种转基因转化体检测方法，制定6项国际标准和 21项国家标准，研制了新型转基因标准物质，为我国转基因检测标准化体系提供核心支撑。