报 告 人: Jin Jiang, Ph.D.

Professor

Eugene Mc Dermott Scholar in Biomedical Research

Phone: 214-645-5914

Fax: 214-648-1960

Email: jin.jiang@utsouthwestern.edu

Webpage: http://www.utsouthwestern.edu/labs/jiang-jin/

报告题目: Exploring Cancer pathways using model organisms: from Hedgehog to Hippo.

报告时间: 2013年3月19日（星期二）上午10:30时
报告地点: 上海交通大学生命学院3-105会议室

联系人：梁婉琪 教授

报告人背景介绍：

Education

B.S.     Fudan University, China, Biochemistry, August. 1986

M.S.    Columbia University-New York, Biology, 1989

M.Ph.  Columbia University-New York, Molecular Biology, 1990

Ph.D.   Columbia University-New York, Developmental genetics, October, 1992

Professional Experience

Jan., 1989 to Dec., 1992

Graduate student with Dr. Michael Levine at Columbia University and UCSD

Molecular analyses of the homeobox gene eve and rel/NF-B related gene dorsal in pattern formation of Drosophila embryo

Jan., 1993 --Apr., 1998

Postdoctoral research fellow with Dr. Gary Struhl in the Howard Hughes Medical Institute at Columbia University College of Physicians and Surgeons,

Genetic and molecular dissection of cell signaling pathways in Drosophila development

May, 1998—Aug., 2003

Assistant Professor, Center for Developmental Biology and Department of pharmacology, UT Southwestern Medical Center at Dallas

Sept., 2003- Aug., 2008

Associate Professor, Department of Developmental Biology and Department of pharmacology, UT Southwestern Medical Center at Dallas

Sept., 2008- present

Honors and Awards

1987-1992  CUSBEA Fellow, Chinese Education Ministry.

1998-2001  Leukemia Society of America Special Fellow.

1998-          Eugene McDermott Scholar in Biomedical Research, UT Southwestern.

1999-2002  Searle Scholar, the Chicago Community Trust

2003-2008   Leukemia & Lymphoma Society Scholar Award

2010-2013  CPRIT Individual Investigator Research Award

Bibliography

a. Research articles

Jin Jiang, Baohua Gu, Lisa M. Albright, and Tracy Nixon. Conservation between Coding and Regulatory Elements of Rhizobium meliloti  and Rhizobium leguminosarum dct  Genes. Journal of Bacteriology, Oct., 1989, p. 5244-5253.

Jin Jiang, Timothy Hoey, and Michael Levine. 1991. Autoregulation of a segmentation gene in Drosophila : combinatorial interaction of the eve-skipped  homeo box protein with a distal enhancer element. Genes & Development  5:265-277.      

Jin Jiang, David Kosman, Tony Ip, and Michael Levine. 1991. The dorsal  morphogen gradient regulates the mesoderm determinant twist  in Drosophila early embryo. Genes & Development  5:1881-1891.

Jin Jiang, Christine Rushlow, Qing Zhou, Steve Small, and Michael Levine. 1992. Individual dorsal binding sites mediate activation  and repression in the Drosophila embryo. EMBO J.  Vol.11, No.8, 3147-3154.

Jin Jiang, Hai-ni Cai, Qing Zhou, and Michael Levine. 1993. Conversion of a silencer into an enhancer: evidence for dorsal  corepressors. EMBO J. Vol. 12, No.8, 3201-3210.

Jin Jiang and Michael Levine. 1993. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the Dorsal gradient morphogen Cell  Vol.72, No.5, 741-752.

Jin Jiang and Gary Struhl. 1995. Protein Kinase A and Hedgehog Signaling in Drosophila Limb Development. Cell Vol. 80, 563-572.

Jin Jiang and Gary Struhl. 1996. Complementary and mutually exclusive activities of Decapentaplegic and Wingless organize axial patterning during Drosophila leg development. Cell Vol. 86, 401-409.

Jin Jiang and Gary Struhl. 1998. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40 protein Slimb. Nature  Vol. 391, 493-496.

Erika Spencer, Jin Jiang, and Zhijian J. Chen. 1999. Signal-induced ubiquitination of IkB by the F-box protein, Slimb/-TrCP. Genes  & Development 13:284-294.

Wang, G., Wang, B., and Jiang, J. 1999. PKA antagonizes Hedgehog Signaling by regulating both the activator and repressor forms of Cubitus interruptus. Genes & Development  13:2828-2837.

Gelin Wang, Kazuhito Amanai, Bing Wang, and Jin Jiang. 2000. Interactions with Costal2 and Suppressor of fused regulates nuclear translocation and activity of Cubitus interruptus. Genes & Development 14: 2893-2905.

Kazuhito Amanai and Jin Jiang. 2001. Distinct roles of Central missing and Disptached in sending the Hedgehog signal. Development 128, 5119-27.

Jianhang Jia, Kazuhito Amanai, Gelin Wang, Bing Wang, Jiong Tan, and Jin Jiang. 2002. Sgg/GSK-3 inhibits Hedgehog signaling by regulating Cubitus interruptus. Nature 416, 548-52.

Hyuk Wan Ko, Jin Jiang, and Isaac Edery. 2002. A role for Slimb in the degradation of Drosophila PERIOD protein phosphorylated by DOUBLETIME. Nature 420, 673-678.

Correia T, Papayannopoulos V, Panin V, Woronoff P, Jiang J, Vogt TF, Irvine KD. 2003. Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. Proc Natl Acad Sci 100(11), 6404-9.

Jianhang Jia, Chao Tong, and Jin Jiang . 2003. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its carboxyl-terminal tail. Genes & Development 17, 2514-2519.

Jianhang Jia, Wensheng Zhang, Bing Wang, Richard Trinko, and Jin Jiang. 2003. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes & Development  17, 2709-2720.

Gelin Wang and Jin Jiang. 2004. Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms. Developmental Biology 268, 493-505.

Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang. 2004. Hedgehog Signalling Activity of Smoothened Requires Phosphorylation by Protein Kinase A and Casein Kinase I. Nature 432, 1045-1050.

Wensheng Zhang, Yun Zhao, Chao Tong, Geling Wang, Bing Wang, Jianhang Jia, and Jin Jiang. 2005. Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Developmental Cell 8, 267-278.

Atish Ganuly, Jin Jiang, and Y. Tony IP. 2005. Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo. Development 132, 3419-3429

Jianhang Jia, Lei Zhang, Qing Zhang, Chao Tong, Bing Wang, Fajian Hou, Kazuhito Amanai, and Jin Jiang. 2005. Phosphorylation of Cubitus interruptus by Double-time/CKI and CKI targets it   for Slimb/-TRCP mediated proteolytic processing. Developmental Cell 9, 819-830.

Qing Zhang, Lei Zhang, Bing Wang, Chan-Yen Ou, Cheng-Ting Chien, and Jin Jiang. 2006. A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor. Developmental Cell 10, 719-729.

Lei Zhang, Jianhang Jia, Bing Wang, Kazuhito Amanai, Keith A. Wharton, Jr.1, and Jin Jiang. 2006. Regulation of Wingless signaling by the CKI family in Drosophila limb development. Developmental Biology 299 (1): 221-237

Ou CY, Wang CH, Jiang J, Chien CT. 2007. Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Developmental Biology 308(1):106-19.

Liu Y, Cao X, Jiang J, Jia J. 2007. Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes & Development 21(15):1949-63.

Yun Zhao, Chao Tong and Jin Jiang. 2007. Hedgehog regulates Smoothened activity by inducing a conformational switch. Nature (Article), 450, 252-258.

Lei Zhang, Fangfang Ren, Qing Zhang, Yongbin Chen, Bing Wang, and Jin Jiang. 2008. The TEAD/TEF  family of transcription factor Scalloped mediates Hippo signaling in organ size control. Developmental Cell 14, 377-387.

Alla Amcheslavsky, Jin Jiang, Y. Tony Ip. 2009. Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4, 49-61.

Hongbo Yang, Jing Xiang, Nengdong Wang, Yun Zhao4 Joel Hyman, Jin Jiang, James K. Chen, Zhen Yang, and Shuo Lin. 2009. Converse conformational control of smoothened activity by structurally related small molecules. Journal of Biological Chemistry 31, 20876-84.

Galletti Margherita, Riccardo Sara, Parisi Federica, Lora Carlina, Rivas Leinny, Wong Bonnie1, Serra  Alexis, Serras Florenci, Grifoni Daniela, Pelicci PierGiuseppe, Jin Jiang, and Bellosta Paola. 2009. Identification of Domains Responsible for Ubiquitin-dependent Degradation of dMyc by GSK3 and CKI kinases. Molecular and Cellular Biology 12, 3424-3434.

Joel M. Hyman, Ari J. Firestone, Vivi M. Heine, Yun Zhao, Cory A. Ocasio, Kyuho Han, Mark Sun, Paul G. Rack, Surajit Sinha, Jason J. Wu, David E. Solow-Cordero, Jin Jiang, David H. Rowitch, James K. Chen. 2009. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. PNAS 106, 14132-14137.

Qing Zhang, Qing Shi, Yongbin Chen, Tao Yue, Shuang Li, Bing Wang, and Jin Jiang. 2009. Multiple Ser/Thr rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. PNAS 106, 21191-21196.

Fangfang Ren, Lei Zhang, and Jin Jiang. 2010. Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biology 337, 303-312.

Hai Song, Kingston Mak, Lilia Topol, Kangsun Yun, Jianxin Hu, Lisa Garrett, Yongbin Chen, Ogyi Park, Jia Chang, R. Mark Simpson, Cun-Yu Wang, Bin Gao, Jin Jiang and Yingzi Yang. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. PNAS 107(4):1431-6.

Yongbin Chen, Shuang Li, Chao Tong, Bing Wang, Yajuan Liu, Jianhang Jia and Jin Jiang. 2010. G protein coupled receptor kinase 2 regulates high-level Hedgehog signaling by promoting the active state of Smo through both kinase dependent and independent mechanisms. Genes & Development, 24, 2054-2067.

Fangfang Ren, Bing Wang, Tao Yue, Eun-Young Yun, Y.Tony Ip & Jin Jiang. 2010. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. PNAS 107(49):21064-9.

Hongge Jia, Yajuan Liu, Ruohan Xia, Chao Tong, Tao Yue, Jin Jiang, and Jianhang Jia. 2010. Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus. Journal of Biological Chemistry 48, 37218-26.

Alla Amcheslavsky, Naoto Ito, Jin Jiang and Y. Tony Ip. 2011. Tuberous Sclerosis Complex restricts the growth but promotes the division of intestinal stem cells in Drosophila. Journal of cell Biology 193, 695-710.

Yongbin Chen, Noriaki Sasai, Guoqiang Ma, Tao Yue, Jianhang Jia, James Briscoe and Jin Jiang. 2011. Sonic Hedgehog Dependent Phosphorylation by CK1 and GRK2 is Required for Ciliary Accumulation and Activation of Smoothened. PLoS Biol 9(6): e1001083. doi:10.1371/journal.pbio.1001083.

Sheu-Fen Lee, Bhooma Srinivasan, Chantelle F. Sephton, Daniel R. Dries, Bing Wang, Colleen M. Dewey, Cong Yu, Pradip K. Majumder, Sanjiv Shah, Jin Jiang, and Gang Yu. 2011. Gamma-secretase-regulated proteolysis of notch by mitochondrial intermediate peptidase. Journal of Biological Chemistry 286, 27447-53.

Qing Shi, Shuang Li, Jianhang Jia and Jin Jiang. 2011. Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development 138, 4219-4231.

Shuang Li, Yongbin Chen, Qing Shi, Tao Yue, Bing Wang, and Jin Jiang, 2012. Hedgehog-regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila. PLoS Biol 10(1): e1001239. doi:10.1371/journal.pbio.

1001239.

Yunyun Jin, Liang Dong, Yi Lu, Wenqing Wu, Qian Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao and Lei Zhang. 2012. Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. Journal of Biological Chemistry 287, 5784-96.

Yuxiao Wang, Huawei He, Nishi Srivastava, Sheikh Vikarunnessa, Yongbin Chen, Jin Jiang, Christopher   Cowan & Xuewu Zhang. 2012. Plexins are GTPase Activating Proteins for Rap and Activated by Induced Dimerization. Science Signaling  5(207):ra6.

Tao Yue, Aiguo Tian, and Jin Jiang. 2012. The cell adhesion molecule Echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Developmental Cell 22, 255-267.

Cuiping Yang, Wenlin Chen, Yongbin Chen and Jin Jiang. 2012. Smoothened transduces Hedgehog   Signal by forming a complex with Evc/Evc2. Cell Res 22:1593–1604.

Zhao Zhang, Xiangdong Lv, Jin Jiang, Lei Zhang, Yun Zhao. 2013. Dual role of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Cell Res, in press.

Fangfang Ren, Qing Shi^, Yongbin Chen, Alice Jiang, Y. Tony Ip, Huaqi Jiang, and Jin Jiang. 2013. Drosophila Myc integrates multiple signaling pathways to regulate intestine stem cell proliferation and differentiation during midgut regeneration. Development, in revision.

Lianxin Hu, Miss Mengxin Yin, Mr. Hongling Huang, Mr. Liguo Zhang, Yi Lu, Prof. Xinyuan Liu, Prof. Rong Zeng, Dr. Jin Jiang, Dr. Yun Zhao. Casein Kinase 2 Mediated Phosphorylation Positively Regulates Yorkie Activity. Submitted.

Aiguo Tian and Jin Jiang. Epithelium-derived and injury-regulated BMP signals govern stem cell self-renewal in Drosophila adult midgut homeostasis and regeneration. Submitted.

b. Review article and book chapter

Jin Jiang. 2002. Degrading Ci: Who is Cul-pable? Genes & Development 16, 2315-2321.

Jianhang Jia and Jin Jiang. 2006. Decoding the Hedgehog Signal in Animal Development. Cell and Molecular Life Science 63, 1249-1265

Jin Jiang. 2006. Regulation of Hedgehog/Gli signaling by due ubiquitination pathways. Cell Cycle 5 (21) 2457 - 2463.

Chao Tong and Jin Jiang. 2007. Using Immunoprecipitation to Study Protein-protein Interactions in Hedgehog Signaling Pathway. Hedgehog Signaling Protocols. Methods in Molecular Biology. Humana Press. 397, 215-230.

Yun Zhao, Chao Tong, and Jin Jiang. 2007. Transducing the Hedgehog Signal across the plasma membrane. Fly 6, 333-336.

Jin Jiang and C-C Hui. 2008. Hedgehog Signaling in Development and Cancer. Developmental Cell 15 801-812.

Lei Zhang, Tao Ye, and Jin Jiang. 2009. Hippo signaling pathway and organize size control. Fly 7, 68-73.

Chi-chung Hui and Jin Jiang. 2011. Hedgehog signaling activation in human cancer and its clinical implications. Springer Book Chapter, 1-17.

Yongbin Chen and Jin Jiang. 2013. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res, in press.