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NAME: Dabing Zhang
Title: Professor
Email: zhangdb@sjtu.edu.cn
Website: zhanglab.sjtu.edu.cn
Phone: 34205073
EDUCATIONS
1 MSc obtained on botany in1994 from Nanjing University
2 PhD obtained on plant molecular geneticsin 1998 from Shanghai Institute of Plant Physiology (SIPP), Chinese Academy of Sciences (CAS).
WOR EXPERIENCES
1 Professor, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University (2004-present).
2 Professor, Agri-Tech Center of Shanghai Academy of Agricultural Sciences (December 2001 to July 2005)
3 Associate Professor, Agri-Tech Center of Shanghai Academy of Agricultural Sciences (June 1999 to November 2001)
4 Assistant Professor, Agri-Tech Center of Shanghai Academy of Agricultural Sciences (From April 1998 to May 1999).
SERVICES
1 Deputy Dean, School of Life Science and Biotechnology, Shanghai Jiao Tong University (2005-present)
2 Director, Department of Life Sciences and Biotechnology, School of Life Science and Biotechnology, Shanghai Jiao Tong University (2005-2010)
3 Handling Editor, Journal of Integrative Plant Biology (2006 –present);
Journal of Plant Physiology (2007–present);
Journal of Genetics & Genomics (2009–present);
Journal of Food Safety & Quality (2009–present).
Journal of Plant Biology (2011-present)
Biotechnology Advance (2012-present)
4 Member, National Biosafety Committee (2005-present)
5 Member, National Standardization Committee on GMOs (2005-present)
6 Member, Chinese Society of Botany, Shanghai Society of Biochemistry and Molecular Biology
7 Faculty Member of Faulty of 1000 (2013-present).
HONOURS
1 A Shanghai Rising-Star by Science and Technology Commission of Shanghai Municipality in 2001;
2 First Class of Progress of Science and Technology Prize in Shanghai in 2004;
3 Shanghai ShuguangScholar by Educational Commission of Shanghai Municipality in 2005;
4 New Century Excellent Talent in Chinese Universities by Ministry of Education in 2005;
5 First Class of Progress of Science and Technology Prize in Ningxia in 2005;
6 The Excellent Prize of MingZhi RUYE Life Science by Shanghai Municipality in 2006.
7 The Distinguished Young Scholar from National Natural Science Funds in 2007.
8 Distinguished Professor in Shanghai Jiao Tong University (2008-present).
9 Yangtse Rive Scholar of Ministry of Education (2009-present).
RESEARCH INTEREST
1）Mechanism of Rice Inflorescence and Spikelet Development:Rice （Oryzasativa）is becoming a model grass plant and has specialized morphologyof inflorescence and spikelet, which determine agricultural yield. We are using various approaches such as forward and reverse genetics, biochemistry, cell biology etc to investigate the molecular mechanism such as MADS-box genes and their regulatory network implicated in the morphogenesis of rice inflorescence and spikelets
2）Molecular Control of Rice Male Reproduction：The life cycle of flowering plants alternates between diploidsporophyte and haploid gametophyte generations. Male gametophytesdevelop in the anther compartment of the stamen withinthe flower, the sporophytic reproductive structure, and requirecooperative functional interactions between gametophytic andsporophytic tissues. During the male reproductive development, there are numerous biological events including cell division, differentiation anddegeneration of somatic tissues consisting of four concentric cell layers surrounding and supporting reproductive cells as they form maturepollen grains through meiosis and mitosis. To understand the mechanismof plant male reproduction, we are using systems biology (genomics, proteomics, metabonomics), genetics,cell biology, biochemistry, structure biologyetc to elucidate the molecular mechanism underlying the cell-to-cell communcations,programmed cell death, fatty acids metabolism and so on during male reproduction.
3）Molecular Characterization of Transgenic Organisms：As more and more transgenic organisms such as maize, soybean etc have been used as food and feed, some consumers concern the safety of transgenic organisms. To develop methods for analyzing transgenic organisms, we are using systems biology approaches such asgenomics, proteomics, metabonomics to establish new methods and standards for characterize transgenic organisms.
SELECTED PAPERS
1. Niu NN, Liang WQ, Yang XJ, Jin WL, Wilson ZA, Hu JP, Zhang DB*. EAT1 promotes tapetal cell death by regulating aspartic proteases during male reproductive development in rice. Nature Communications. DOI: 10.1038/ncomms2396.
2. Zhang H, Xu C, He Y, Zong J, Yang XJ, Si HM, Sun ZX, Hu JP, Liang WQ, Zhang DB*. Mutation in CSA creates a new photoperiod-sensitive genic male sterile line applicable for hybrid rice seed production. PNAS. 110(1) (2013), 76-81.
3. Tan HX, Liang WQ, Hu, JP Zhang DB*. MICROSPORE AND TAPETUM REGULATOR 1 encodes a secretory fasciclin glycoprotein required for male reproductive development in rice. Developmental Cell. 22(6) (2012), 1127-1137.
4. Wang CM, Marshall A, Zhang DB, Wilson ZA*, ANAP: an integrated knowledge base for Arabidopsis protein interaction network analysis. Plant Physiology. 158(4) (2012), 1523-1533.
5. Li W, Cui X, Meng ZL, Huang X, Xie Q, Wu H, Jin HL, Zhang DB, Liang WQ*, Transcriptional regulation of Arabidopsis MIR168a and ARGONAUTE1 homeostasis in ABA and abiotic stress responses. Plant Physiology. 158(3) (2012), 1279-1292.
6. Chen WW, Yu XH, Zhang K, Shi JX, Schreiber L, Shanklin J, Zhang DB*, Male Sterile 2 encodes a plastid-localized fatty acyl ACP reductase required for pollen exine development in Arabidopsis thaliana. Plant Physiology. 157(2) (2011), 842-853.
9. Li HF, Liang WQ, Hu Y, Zhu L, Yin CS, Xu J, Dreni L, Kater MM, Zhang DB*, Rice MADS6 interacts with the floral homeotic genes SUPERWOMAN1, MADS3, MADS58, MADS13, and DROOPING LEAF in specifying floral organ identities and meristem fate. The Plant Cell. 23(7) (2011), 2536-2552.
10. Shi J, Tan HX, Yu XH, Liu YY, Liang WQ, Ranathunge K, Franke RB, Schreiber L, Wang YJ, Kai GY, Shanklin J, Ma H, Zhang DB*, Defective Pollen Wall (DPW) is required for anther and microspore development in rice and encodes a fatty acyl ACP reductase. The Plant Cell. 23(6) (2011), 2225-2246.
11. Li H, Yuan Z, Vizcay-Barrena G, Yang CY, Liang WQ, Zong J, Wilson Z, Zhang DB*. PERSISTENT TAPETAL CELL 1(PTC1) encodes a PHD-finger protein that is required for tapetal cell death and pollen development in rice. Plant Physioloy. 156(2) (2011), 615-630.
12. Li HF, Liang WQ, Yin CS, Zhu L, and Zhang DB*. Genetic interaction of OsMADS3, DROOPING LEAF and OsMADS13 in specifying rice floral organs identities and meristem determinacy. Plant Physioloy. 156(1) (2011), 263-247.
13. Wang CM and Zhang DB*. A novel compression tool for efficient storage of genome resequencing data. Nucleic Acids Research.39(7) (2011), e45.
14. Hu LF, Liang WQ, Yin CS, Cui X, Zong J, Wang X, Hu JP and Zhang DB*. Rice MADS3 regulates ROS homeostasis during late anther development. The Plant Cell.23(2) (2011), 515-533.
15. Zhang Z, Zhang Y, Tan HX,Wang Y, Li G, Liang WQ, Yuan Z, Hu JP, Ren HY, and Zhang DB*. RICE MORPHOLOGY DETERMINANT encodes the type II formin FH5 and regulates rice morphogenesis. The Plant Cell.23(2) (2011), 681-700.
16. Xu J, Yang CY, Yuan Z, Zhang DS, Gondwe MY, Ding ZW, Liang WQ, Zhang DB*, and Wilson ZA. Regulatory network ofABORTED MICROSPORES (AMS) required for postmeiotic male reproductive development in Arabidopsis thaliana. The Plant Cell.22(1) (2010), 91-107.
17. Wang CM, Xu J, Zhang DS, Wilson ZA, and Zhang DB*. An effective approach for identification of in vivo protein-DNA binding sites from paired-end ChIP-Seq data. BMC Bioinformatics. 11 (2010), 81.
18. Li H, Pinot F, Sauveplane V, Werck-Reichhart D, Diehl P, Schreiber L, Franke R, Zhang P, Chen L, Gao YW, Liang WQ, andZhang DB*. CYP704B2 catalyzing the ω-hydroxylation of fatty acids is required for anther cutin biosynthesis and pollen exine formation in rice. The Plant Cell.22(1) (2010), 173-190.
19. Li H, and Zhang DB*. Biosynthesis of anther cuticle and pollen exine in rice. Plant Signaling & Behavior. 5(9) (2010), 1121-1123.
20. Li HF, Liang WQ, Jia RD, Yin CS, Zong J, Kong HZ, and Zhang DB*. The AGL6-like gene OsMADS6 regulates floral organ and meristem identities in rice. Cell Research. 20(3) (2010), 299-313.
21. Hu LF, Tan HX, Liang WQ, and Zhang DB*. The Post-meiotic Deficient Anther1 (PDA1) gene is required for post-meiotic anther development in rice. Journal Genetics Genomics.37(1) (2010), 1-10.
22. Zhang H, Liang WQ, Yang XJ, Luo X, Jiang N, Ma H, and Zhang DB*. Carbon Starved Anther (CSA) encoding a MYB domain protein regulates sugar partitioning required for rice pollen development. The Plant Cell.22(3) (2010), 672-689.
23. Zhang X, Zong J, Liu JH, Yin JY and Zhang DB*. Genome-wide analysis of WOX gene family in rice, sorghum, maize,Arabidopsis and poplar. Journal of Integrative Plant Biology.52 (11) (2010), 1016-1026.
24. Zhang DS, Liang WQ, Yin C, Zong J, Gu F, and Zhang DB*. OsC6, encoding a lipid transfer protein (LTP), is required for postmeiotic anther development in rice. Plant Physiology. 154(1) (2010), 149-162.
26. Liu ZH, Bao WJ, Liang WQ, Yin JY, and Zhang DB*. Identification of gamyb-4 and analysis of the regulatory role of GAMYB in rice anther development. Journal of Integrative Plant Biology.52(7) (2010), 670-678.
27. Gao XC, Liang WQ, Yin CS, Ji SM, Wang HM, Su X, Guo CC, Kong HZ, Xue HW, Zhang DB*. The SEPALLATA-like geneOsMADS34 is required for rice inflorescence and spikelet. Plant Physiology. 153(2) (2010), 728-740.
29. Guan XY, Guo JC, Shen P, Yang LT, and Zhang DB*, Visual and rapid detection of two genetically modified soybean events using Loop-mediated Isothermal Amplification method, Food Analytical Methods. 3(4) (2010), 313-320.
30. Liu DE, Shen J, Yang LT, Zhang DB*. Evaluation of the impacts of different nuclear DNA content in the hull, endosperm, and embryo of rice seeds on GM rice quantification. Journal of Agriculture Food Chemistry. 58(8) (2010), 4582-4587.
31. Wang C, Jiang LX, Rao J, Liu YN, Yang LT, Zhang DB*. Evaluation of four genes in rice for their suitability as endogenous reference standards in quantitative PCR. Journal of Agriculture Food Chemistry.58(22) (2010), 11543-11547.
33. Wei JL, Xu M, Zhang DB*, and Mi HL*. The role of carotenoid isomerase in maintenance of photosynthetic oxygen evolution in rice plant. ActaBiochimicaetBiophysicaSinica. 42(7) (2010), 457-63.
34. Yuan Z, Gao S, Xue DW, Luo D, Li LT, Ding SY, Yao X, Wilson ZA, Qian Q, and Zhang DB*. RETARDED PALEA1 (REP1) controls palea development and floral zygomorphy in rice. Plant Physiology. 149(1) (2009), 235-244.
35. Zhang DB*, and Wilson ZA. Stamen specification and anther development in rice. Chinese Science Bulletin.54(14) (2009), 2342-2353.
36. Wilson ZA*, and Zhang DB.From Arabidopsis to rice, pathways in pollen development. Journal of Experimental Botany.60(5) (2009), 1479-1492.
37. Zong J, Yao X, Yin JY, Zhang DB* and Ma H*. Evolution of the RNA dependent RNA polymerase (RdRP) genes, duplications and possible losses before and after the divergence of major eukaryotic groups. Gene. 447(1) (2009), 29-39.
38Guo JC, Yang LT, Liu X, Zhang HB, Qian BJ, and Zhang DB*.Applicability of the Chymopapain gene used as endogenous reference gene for transgenic Huanong No,1 papaya detection. Journal of Agriculture Food Chemistry.57(15) (2009), 6502-6509.
43. Guo JC, Yang LT, Liu X, Guan XY, Jiang LX, and Zhang DB*. Characterization of the exogenous insert and development of event-specific PCR detection methods for genetically modified Huanong No, 1 papaya. Journal of Agriculture Food Chemistry.57(16) (2009), 7205-7212.
44. Jiang LX, Yang LT, Zhang HB, Guo JC, Marco M, Van den EG, and Zhang DB*. International collaborative study of the endogenous reference gene, Sucrose Phosphate Synthase (SPS), used for qualitative and quantitative analysis of genetically modified rice. Journal of Agriculture Food Chemistry. 57(9) (2009),3525-3532.
45. Yang LT, Zhang HB, Guo JC, Pan LW, and Zhang DB*. International collaborative study for the endogenous reference gene,LAT52, used for qualitative and quantitative analysis of genetically modified tomato. Journal of Agriculture Food Chemistry.56(10) (2008), 3438-3443.
50. Dong W, Yang LT, Shen KL, Kim BH, Kleter GA, Marvin HJP, Guo R, Liang WQ, and Zhang DB*. GMDD, a database of GMO detection methods. BMC Bioinformatics. 9 (2008), 260.
51. Yang LT, Liang WQ, Jiang LX, Li WQ, Cao W, Wilson ZA, and Zhang DB*, A novel universal real-time PCR system using the attached universal duplex probes for quantitative analysis of nucleic acids. BMC Molecular Biology.9 (2008), 54.
52. Zhang DS, Liang WQ, Yuan Z, Lia N, Shi J, Wang J , Liu YM, Yu WJ, and Zhang DB*. Tapetum Degeneration Retardation is critical for aliphatic metabolism and gene regulation during rice pollen development. Molecular Plant. 1(4) (2008), 599-610.
53. Yang LT, Guo JC, Pan AH, Zhang HB, Zhang KW, Wang ZM, and Zhang DB*. Event-specific quantitative detection of nine genetically modified maizes using one novel standard reference molecule. Journal of Agriculture Food Chemistry.55(1) (2007), 15-24.
54 Shi XZ, Wu AB, Qu GR, Li RX, and Zhang DB*. Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs. Biomaterials. 28(25) (2007), 3741-3749.
55. Chu HW, and Zhang DB*. The shoot apical meristem size regulated by FON4 in rice. Plant Signaling & Behavior, 2(2) (2007), e1-e2.
56. Li N, Zhang DS, Liu HS, Yin CS, Li XX, Liang WQ, Yuan Z, Xu B, Chu HW, Wang J, Wen TQ, Huang H, Luo D, Ma H, and Zhang DB*. The rice Tapetum Degeneration Retardation gene is required for tapetum degradation and anther development. The Plant Cell.18(11) (2006), 2999-3014.
57. Chu HW, Qian Q, Liang WQ, Yin CS, Tan HX, Yao X, Yuan Z, Yang J, Huang H, Luo D, Ma H, and Zhang DB*. The FLORAL ORGAN NUMBER4 gene encoding a putative ortholog of Arabidopsis CLAVATA3 regulates apical meristem size in rice. Plant Physiology. 142(3) (2006), 1039-1052.
58. Li XX, Duan XP, Jiang HX, Sun YJ, Tang YP, Yuan Z, Guo JK, Liang WQ, Chen L, Wang J, Ma H, Yin JY, and Zhang DB*. Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis. Plant Physiology. 141(4) (2006), 1167-1184.
59. Jiang DH, Yin CS, Yu AP, Zhou XF, Liang WQ, Yuan Z, Xu Y, Yu QB, Wen TQ, and Zhang DB*. Duplication and expression analysis of multicopymiRNA gene family members in Arabidopsis and rice. Cell Research. 16(5) (2006), 507-518.
60. Qian BJ, Shen HF, Xiong JJ, Chen L, Zhang L, Jia JW, Wang Y, Zhang ZC, Yuan Z, Cao KM, and Zhang DB*. Expression and purification of the synthetic preS1 gene of Hepatitis B Virus with preferred Escherichia coli codon preference. Protein Expression and Purification. 48(1) (2006), 74-80.
61. Yang LT, Pan AH, Zhang KW, Yin CS, Qian BJ, Chen JX, Huang C, and Zhang DB*. Qualitative and quantitative PCR methods for event-specific detection of genetically modified cotton Mon1445 and Mon531. Transgenic Research. 14(6) (2005), 817-831. (*通讯作者).
62. Yang LT, Pan AH, Zhang KW, Guo JC, Yin CS, Chen JX, Huang C, and Zhang DB*. Identification and quantification of three genetically modified insect resistant cotton lines using conventional and TaqMan real-time polymerase chain reaction methods.Journal of Agriculture Food Chemistry. 53(16) (2005), 6222-6229.
63.Yang LT, Chen JX, Huang C, Jia SR, Liu YH, Pan LW, and Zhang DB*. Validation of a cotton specific gene, Sad1, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic cottons. Plant Cell Reporter.24 (4) (2005), 237-245.
64.Yang LT, Xu SC, Pan AH, Yin CS, Zhang KW, Wang ZY, Zhou ZG, and Zhang DB*. Event-specific qualitative and quantitative PCR detection of genetically modified MON863 maize based on the 5’-transgene integration sequence. Journal of Agriculture Food Chemistry.53(24) (2005), 9312-9318.
65.Weng HB, Yang LT, Liu ZL, Ding JY, Pan AH, and Zhang DB*. A novel reference gene, High-mobility-group protein I/Y,can be used in qualitative and real-time quantitative PCR detection of transgenic rapeseeds.Journal of AOAC International. 88(2) (2005), 577-584.
66.Yang LT, Ding JY, Zhang CM, Jia JW, Weng HB, Liu WX, and Zhang DB*. Estimating the copy number of transgenes in transformed rice by real-time quantitative PCR. Plant Cell Reporter.23(10-11) (2005), 759-763.
67. Yang LT, Pan AH, Jia JW, Ding JY, Chen JX, Huang C, Zhang CM, and Zhang DB*. Validation of a tomato specific gene,LAT52, used as an endogenous reference gene in qualitative and real-time quantitative PCR detection of transgenic tomatoes.Journal of Agriculture Food Chemistry. 53(2) (2005), 183-190.
68. Liu HS, Chu HW, Hui Li, Wang HM, Wei JL, Li N, Ding SY, Huang H, Ma H, Huang CF, Luo D, Yuan Z, Liu JH, and Zhang DB*. Genetic analysis and mapping of rice (Oryza sativa L,) male-sterile (OsMS-L) mutant. Chinese Science Bulletin. 50(2) (2005) ,122-125.
69. Li H, Xu L, Wang H, Yuan Z, Cao XF, Yang ZN, Zhang DB, Xu Y, and Huang H*, The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsisleaf development. The Plant Cell, 17(8) (2005), 2157-2171.
70. Ding JY, Jia JW, Yang LT, Wen HB, Zhang CM, Liu WX, and Zhang DB*.Validation of a rice specific gene, Sucrose Phosphate Synthase, used as the endogenous reference gene for qualitative and real-time quantitative PCR detection of transgenes. Journal of Agriculture Food Chemistry.52(11) (2004), 3372-3377.
71. Weng HB, Pan AH, Yang LT, Zhang CM, Liu ZL,and Zhang DB*. Estimating transgene copy number by real-time PCR assay using HMG I/Y as an endogenous reference gene in transgenic rapeseed. Plant Molecular Biology Reporter.22(3) (2004), 289-300.
72. Huang YH, Liang WQ, Pan AH, Zhou ZA,Cheng H, Chen JX, and Zhang DB*. Production of FaeG, the major subunit of K88 fimbriae, in transgenic tobacco plants and its immunogenicity in mice. Infection and Immunity.71(9) (2003), 5436-5439.
73. Zhang YL, Zhang DB*, Li WQ, Chen JQ, Peng YF, and Cao W. A novel real-time quantitative PCR method using attached universal template probe. Nucleic Acids Research.31(20) (2003), e123.
74. Meng YL, Wang YM, Zhang DB, and NII NS. Isolation of a choline monooxygenasecDNA clone from Amaranthus tricolor and its expressions under stress conditions. Cell Research. 11(3) (2001), 187-193.
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